1⟩ Explain All of the following agents are beta receptor agonists EXCEPT Epinephrine Isoproterenol Methoxamine Dobutamine?
Methoxamine
Pharmacology
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21 Pharmacology Questions And Answers
2⟩ Explain Do you know how the dose for children is being estimated based on preclinical data?
There are a number of ways of estimating children's doses from preclinical (adult) data - often depends on the therapeutic index of the drug in question (the wider the therapeutic window the less accurate the child's dose needs to be). Sometimes straight weight-basis i.e. 7kg child gets 1/10 dose of 70kg adult.
More accurate (so they say) is a dose based on body surface area (child's surface area is greater in proportion to its body weight than an adult is). There are normograms to calculate surface area from weight and height of child.
All of these may be wrong if clearance of drug in child is significantly different from adult e.g. different metabolism or different route of clearance.
3⟩ Explain Which of the following barbiturates is an ultra-short-acting drug? Secobarbital Amobarbital Thiopental Phenobarbital?
Thiopental
4⟩ Explain DOC for cisplatin induced vomitting metaclopramide domperidone ondansetron prochlorperazine?
ondansetron
5⟩ Explain Ciprofloxacin act by Inhibiting protein synthesis Inhibiting DNA function Inhibiting cell wall synthesis Inhibiting glycolysis?
Inhibiting DNA function
6⟩ Indicate the irreversible alfa receptor antagonist Tolazoline Labetalol Prazosin Phenoxybenzamine
Phenoxybenzamine
7⟩ MOA of moricizine prolongs APD shortens APD no change in APD calcium channel blecker
prolongs APD
8⟩ Explain which of the following antitubercular drug contraindicated in pragnancy. INH ethambutol rifampicin streptomycin
streptomycin
9⟩ Explain Hypnotic drugs are used to treat Psychosis Sleep disorders Narcolepsy Parkinsonian disorders
Sleep disorders
10⟩ Indicate a beta receptor antagonist, which has very long duration of action Metoprolol Propranolol Nadolol Pindolol
Nadolol
11⟩ Explain Which of the following is not used in enterococcal infection? Vancomycin Linezolide Teichoplanin Cephalexin
Cephalexin
12⟩ Explain Oral contraception failure can occur with A/E ampicillin phenytoin rifampicin mebendazole
mebendazole
13⟩ Explain Which of the following benzodiazepines is used mainly for hypnosis? Clonozepam Lorazepam Flurazepam Midazolam
Flurazepam
14⟩ Explain Which of the following is an antifungal Flucytosin Cytosine arabinoside 5 fluourasil Procarbazine
Flucytosin
15⟩ Explain the hypnotic drugs induce Increase the duration of REM sleep Decrease the duration of REM sleep Do not alter the duration of REM sleep Increase the duration of slow wave sleep
Decrease the duration of REM sleep
16⟩ Explain indirect-acting adrenoreceptor blocking drug Tolazoline Reserpine Carvedilol Prazosin
Reserpine
17⟩ Explain Flumazenil blocks the actions of Phenobarbital Morphine Zolpidem Ethanol
Zolpidem
18⟩ Explain Which of the following hypnotic agents is absorbed slowly? Phenobarbital Flurazepam Triazolam Temazepam
Temazepam
19⟩ Explain with an example of haemopoietic growth factor is platelet derived growth factor epidermal growth factor iron dextran erythropoietin
erythropoietin
20⟩ Explain Dose of acetaminophen in children 5-10mg/kg/day 5-10mg/kg/dose 10-15mg/kg/day 10-15mg/kg/dose
10-15mg/kg/dose
