Just because you've never done something doesn't mean you can't do it. And it surely doesn't mean you can't excel at it. If you're asked a question about prior experience regarding something you've never done, the best way to answer isn't to say "No, I've never done that." Or, "No, I don't have experience in that area." The best way to handle the question is to say something along these lines: While I have not had any direct experience in XYZ, I am a fast learner, and I am confident that I could (do, manage, direct, handle, etc.) XYZ successfully and exceed your expectations. And an effective way to enhance your previous confident response would be to share with the hiring manager about a time when you did do something very similar-or something that could in some way relate to the experience they are asking you about.