There are a multitude of responses to this question, including: decisions involving others, decisions with a large impact, or decisions which involve large sums of money.

It’s acceptable to say that you’re more cautious with any difficult decision, but you want to show the interviewer you’re willing to make difficult decisions (and do so logically). Nobody likes to hold another person’s hand in the workplace, so the person they will hire is someone who they can trust in tough situations.