Likewise simple diffusion facilitated diffusion is more intense when the concentration gradient of the substance increases and less intense when the gradient lessens. In facilitated diffusion however there is a limiting factor: the quantity of the permeases that facilitate the transport through the membrane. Even in a situation in which the concentration gradient of the diffusing substance increases, if there are not enough permeases to perform the transport there will be no increase in the intensity of the diffusion. This situation is called saturation of the transport proteins and it represents the point in which the maximum transport capacity of the substance across the membrane is achieved.