The thing I like most about being a nuclear medicine physician is being able to make a difference in a patient’s care. This is most often in the form of giving feedback in the form of F-18 FDG PET/CT to let the patient’s oncologists or radiation oncologists know how the treatment is working. But, this is a tie with being able to give radionuclide therapies either to prolong survival with patients who have differentiated thyroid cancer or give palliative therapy for pain in patients with widespread osseous metastatic disease. Being able to make a difference for patients is very rewarding.