Flask is a “microframework” primarily build for a small application with simpler requirements. In flask, you have to use external libraries. Flask is ready to use.

Pyramid are build for larger applications. It provides flexibility and lets the developer use the right tools for their project. The developer can choose the database, URL structure, templating style and more. Pyramid is heavy configurable.

Like Pyramid, Django can also used for larger applications. It includes an ORM.